This website is intended for US healthcare professionals only. Prescribing Information Important Safety Information

Sans Titre 2Desktop

What is protein C deficiency?

Protein C deficiency can be caused by mutation of the protein C gene (congenital protein C deficiency) or as a result of other conditions (acquired protein C deficiency).1,2 The severity of the deficiency is determined by the remaining plasma activity of protein C.1

Severe Congenital Protein C Deficiency (SCPCD) is an autosomal recessive, rare disorder that leads to high initial mortality and long-term morbidity in survivors2. In neonates, SCPCD can manifest, within hours after birth, as purpura fulminans with necrosis of the skin and venous thrombosis.1-3

Which tests confirm SCPCD?Resources for your patients


The severity of protein C deficiency is based on protein C activity1


*Adult levels

The mean plasma concentration of protein C in a healthy term infant is 40 IU dL, with a lower limit of normal of 25 IU dL.
Protein C concentration increases from birth until 6 months of age. Protein C concentration remains slightly low through childhood and achieves the adult range after puberty.

Click arrow for Indication and Important Safety Information

Warnings and Precautions

Hypersensivity: CEPROTIN may contain trace amounts of mouse protein and/or heparin as a result of the manufacturing process. Allergic reactions to mouse protein and/or heparin cannot be ruled out. If symptoms of hypersensitivity/allergic reaction occur, discontinue the injection/infusion. In case of anaphylactic shock, the current medical standards for treatment are to be observed.


  1. Goldenberg N, Manco-Johnson M. Protein C deficiency. Haemophilia. 2008;14(6):1214–1221.

  2. Chalmers E, et al. Purpura fulminans: recognition, diagnosis and management. Archives of Disease in Childhood. 2011;96(11):1066-1071.

  3. Price VE, et al. Diagnosis and management of neonatal purpura fulminans. Semin Fetal Neonatal Med. 2011;16(6):318-22.

Sign up below

The contact information collected in this form will be used for subscribing to our newsletter and updates on educational activities.

Sorry! There are some errors below that need to be fixed.

You have the right to opt out of receiving such electronic communications and/or our newsletter, at any time, by using the opt out link in the communication or by contacting us at or by calling 1-866-888-0660. For more information on how Takeda processes your personal data, please refer to our Privacy Notice

Please include @ in your email address (eg


Thank you for submitting your details.

You are about to leave this website
Please be advised that Takeda has no control over the content or presentation of the site your are to view. Takeda's Privacy Notice does not apply to the website you are about to visit.
Continue Cancel