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Early diagnosis of
Severe Congenital Protein C Deficiency

Identification of Severe Congenital Protein C Deficiency (SCPCD)

Clinical diagnosis of purpura fulminans skin lesions is critical

  • Visually identifying skin lesions:
    • Infants with SCPCD usually present within hours after birth with rapidly progressive purpura fulminans1,2
  • Because purpura fulminans is a hematological emergency due to the rapidly progressive nature of the multi-organ thrombotic injury, consultation with a hematologist is recommended3


Which tests confirm SCPCD ?

SCPCD and its potential complications3

Purpura fulminans can lead to life-threatening complications:

  • Purpura fulminans can rapidly progress to organ failure as a result of necrosis and disseminated intravascular coagulation3
  • Rates of amputation with purpura fulminans may be as high as 62%4

Acute treatment of PF and VT with CEPROTIN

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Warnings and Precautions

Hypersensivity: CEPROTIN may contain trace amounts of mouse protein and/or heparin as a result of the manufacturing process. Allergic reactions to mouse protein and/or heparin cannot be ruled out. If symptoms of hypersensitivity/allergic reaction occur, discontinue the injection/infusion. In case of anaphylactic shock, the current medical standards for treatment are to be observed.


  1. Goldenberg N, Manco-Johnson M. Protein C deficiency. Haemophilia. 2008;14(6):1214-1221.

  2. Price VE, et al. Diagnosis and management of neonatal purpura fulminans. Semin Fetal Neonatal Med. 2011;96(6):318-22.

  3. Chalmers E, et al. Purpura fulminans: recognition, diagnosis and management. Archives of Disease in Childhood. 2011;96(11):1066-1071.

  4. Gürgey A, et al. Outcome in Children With Purpura With Fulminans: Report on 16 Patients. Am J Hematol. 2005;80(1):20-5.

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