This website is intended for US healthcare professionals only. Prescribing Information Important Safety Information

Template Desktop

CEPROTIN manufacturing

CEPROTIN is a non-activated protein C concentrate purified from human plasma1,2

CEPROTIN is derived from human plasma and passes through a rigorous manufacturing process to reduce the risk of viral transmission that is normally associated with plasma based products1. CEPROTIN goes through a detergent treatment, heat inactivation and human immunoaffinity chromatography to ensure either the removal or inactivation of human immunodeficiency virus (HIV), hepatitis A, B and C virus and parvovirus B191. Because CEPROTIN is made from human plasma, it may carry a risk of transmitting infectious agents, e.g., viruses, the variant Creutzfeld-Jakob disease (vCJD) agent, and theoretically, the Creutzfeld-Jakob disease agent. ALL infections suspected by a physician possibly to have been transmitted by this product should be reported by the physician or other healthcare provider to Takeda Inc., at 800-828-2088. Discuss the risks and benefits of this product with your patient.1

CEPROTIN manufacturing process3

CEPROTIN manufacturing process

Click arrow for Indication and Important Safety Information

Warnings and Precautions

Hypersensivity: CEPROTIN may contain trace amounts of mouse protein and/or heparin as a result of the manufacturing process. Allergic reactions to mouse protein and/or heparin cannot be ruled out. If symptoms of hypersensitivity/allergic reaction occur, discontinue the injection/infusion. In case of anaphylactic shock, the current medical standards for treatment are to be observed.


  1. CEPROTIN [Protein C Concentrate (Human)] Prescribing information. Lexington, MA: Baxalta US Inc.
  2. Goldenberg N, Manco-Johnson M. Protein C deficiency. Haemophilia. 2008;14(6):1214–1221.

  3. Knoebl PN. Human protein C concentrates for replacement therapy in congenital and acquired protein c deficiency. Drugs Today. 2008;44:429-441.

Sign up below

The contact information collected in this form will be used for subscribing to our newsletter and updates on educational activities.

Sorry! There are some errors below that need to be fixed.

You have the right to opt out of receiving such electronic communications and/or our newsletter, at any time, by using the opt out link in the communication or by contacting us at or by calling 1-866-888-0660. For more information on how Takeda processes your personal data, please refer to our Privacy Notice

Please include @ in your email address (eg


Thank you for submitting your details.

You are about to leave this website
Please be advised that Takeda has no control over the content or presentation of the site your are to view. Takeda's Privacy Notice does not apply to the website you are about to visit.
Continue Cancel